Central Massachusetts GuideCentral Massachusetts, also referred to as Central Mass. is a region in the Commonwealth of Massachusetts, in the United States of America. It encompasses part of the Blackstone Valley National Corridor in the southern part of the region. HotelsFind hotels in Worcester, Sturbridge, Framingham, Sudbury, Natick and more. WorcesterWorcester is in central Massachusetts approximately 45 mi. west of Boston. Worcester was established as a town on June 14, 1722 and as a city on February 29, 1848. SturbridgeSturbridge is a charming New England town located in southern Central Massachusetts approximately 60 miles west of Boston. FraminghamFramingham is a large town in Massachusetts, with a population of more than 67,000. MetroWestMetro West is a region just west of Greater Boston in Massachusetts. Routes I-495 and I-90 make for easy exploration by car of areas in all directions. Blackstone ValleyBlackstone Valley is a region of Central Massachusetts extending from Worcester southeast toward Providence, Rhode Island. South CountySouth County is in Central Massachusetts. It is the southwest area of Worcester County. North CountyNorth County is a region in the northern part of Central Massachusetts. QuabbinThe Quabbin Reservoir is a man-made body of water located in Central Massachusetts.