Central New York GuideThe Central region of New York is a crossroads, dominated by the state's fifth-largest city, Syracuse, and the Mohawk River that flows eastward through this region. HotelsFind hotels in Syracuse, Utica, Cooperstown and more. SyracuseSyracuse is a city in Central New York. It is the fifth largest city in the state of New York, and the third largest in Upstate New York. UticaUtica is a city in Central New York. The Utica-Rome area, situated between Syracuse and Albany, is served by Interstate 90. MohawkMohawk is a town in Central New York State. Mohawk is a small town of around 2,500 residents located on the Mohawk River. CooperstownCooperstown, in Central New York, is known best for its role as the Home of the National Baseball Hall of Fame and Museum. MiddlevilleMiddleville is in Central New York. PulaskiPulaski is a village in Central New York. Driving: Pulaski is Exit 37 on I-81. Around half an hour north of Syracuse and half an hour south of Watertown. CortlandCortland is a city in Central New York. Driving: Cortland is Exit 11 and 12 on I-81. Sharon SpringsSharon Springs is in Central New York. A former spa town which then fell into disrepair, Sharon Springs has had a revival as a getaway destination for people from New York City. ClintonClinton is a city in New York. BainbridgeBainbridge is a city in New York. Antique shopping at several antique stores along route 41: Main Street Antiques Iroquois Antiques RomeRome is a small city in Central New York State, not far from Utica. New HartfordNew Hartford is a city in New York. ClayClay is a city in New York State. Closest sleep is in Liverpool.