Midwest GuideThe Midwest is a region of the United States of America known as "America's Heartland", which refers to its primary role in the nation's manufacturing and farming sectors as well as its patchwork of big commercial cities and small towns that, in combination, are considered as the broadest representation of American culture. HotelsFind hotels in Chicago, Indianapolis, Ann Arbor, Cincinnati, Minneapolis and more. ChicagoChicago is the home of the blues and the truth of jazz, the heart of comedy and the idea of the skyscrapers. IndianapolisIndianapolis is in the Nine-County Region of Indiana, right at the center of the state. Ann ArborAnn Arbor—often abbreviated as AA or A2—is a city in Michigan 35 miles north of the Ohio border and 45 miles west of Detroit, near where the furthest exurban fringes give way to country and small towns. IllinoisIllinois is a state in the Midwest of the United States of America. Central Illinois Chicagoland Northern Illinois Saint Louis … OhioOhio is a state in the Midwest region of the USA. The state has natural boundaries to the north and to the south and is bordered by the states of Indiana, Kentucky, Michigan, Pennsylvania and West Virginia. MichiganMichigan is an American state in the upper Midwest and the heart of the Great Lakes region. IndianaIndiana is a state in the Midwest region of the USA. The state is bordered by Ohio, Kentucky, Illinois, and Michigan. MinnesotaMinnesota is a state in the Midwest of the USA. Known as the Land of 10,000 Lakes, it technically has well over 15,000. WisconsinWisconsin is a state in the Midwest in the United States of America. The name Wisconsin means "meeting of the waters" and is of Native American origin. MissouriMissouri is a state in the American Midwest known as the "Show-Me State". The name is pronounced "missouri" or "missouruh", although the latter is very seldom heard outside of Missouri. IowaIowa, a state in the Midwest of the United States of America, was admitted to the Union in 1846 as the 29th state.