Povardarie GuidePovardarie is the central region of Macedonia, along the Vardar River. It includes the country's capital and largest city, Skopje. Povardarie, forming the central stretch of Macedonia between Serbian and Greek borders, is a land of mountains, canyons, and valleys, dominated by the River Vardar, the longest river of the country. HotelsFind hotels in Skopje, Kavadarci, Skopje and more. SkopjeSkopje is the capital of the Republic of Macedonia; it is in the Povardarie region, and is the largest and most diverse city in the country. Demir KapijaDemir Kapija is a town located in the Povardarie region of the Republic of Macedonia. StobiStobi is a large set of ruins in the Povardarie region of Macedonia. Stobi was once the ancient town of Paionia, later conquered by Macedon, and later still incorporated into the Roman province of Macedonia Salutaris. VelesVeles is a city located in the Povardarie region of Macedonia. It has about 46,000 residents. KavadarciKavadarci is the wine capital of Macedonia, located in the Tikveš grape growing region of Povardarie. NegotinoNegotino is a city in the Povardarie region of Macedonia. Negotino is located on the main highway E-75.