Southern California GuideSouthern California is a megapolitian area in the southern region of the U.S state of California. The large urban areas comprised of Los Angeles and San Diego stretch all along the coast from Ventura to the Southland and Inland Empire to San Diego. HotelsFind hotels in Los Angeles, San Diego, Long Beach, Anaheim and more. Los AngelesThe city of Los Angeles is the most populous city in California. Located on a broad basin in Southern California, the city is surrounded by vast mountain ranges, valleys, forests, the Pacific Ocean, and nearby desert. San DiegoFrom balmy beaches with a laid-back attitude to a gleaming modern image, San Diego offers much for the tourist to enjoy. Long BeachLong Beach is a large port city in Los Angeles County in Southern California. Long Beach is a large coastal and port city in Southern California. Los Angeles CountyLos Angeles County is a region of thousands of square miles in Southern California roughly the same size as Rhode Island. San Diego CountySan Diego County is the southwestern-most region of Southern California. It encompasses the city of San Diego and its large metropolitan area, which includes many smaller cities and communities. Orange CountyOrange County is a county in Southern California. A patchwork of 34 independent municipalities, Orange County's population is one of the most culturally diverse in the world. Riverside CountyRiverside County is a county in Southern California which extends east into the California Desert. San Bernardino CountySan Bernardino County, the largest county in the state, is a county that spans the Southern California and Desert regions of the state of California. Inland EmpireThe Inland Empire of California is a semi-arid region, east of Los Angeles, made up of scores of cities and towns.