Tennessee GuideTennessee is a US state in the South. Each region is known for its distinctive musical heritage: Bluegrass, Country-western, and Blues. Many native Tennesseans speak in the dialect of the American South. HotelsFind hotels in Chattanooga, Nashville, Memphis, Knoxville, Clarksville and more. ChattanoogaChattanooga is the 4th largest city in Tennessee. It is the seat of Hamilton County. NashvilleNashville is a city in Davidson County and the capital of the American state of Tennessee. MemphisMemphis is the largest city in the state of Tennessee. The state rests in the southeastern portion of the United States. Eastern TennesseeEastern Tennessee is a region of Tennessee. Central TennesseeCentral Tennessee is a region of Tennessee. The Natchez Trace Parkway crosses through Middle Tennessee. Western TennesseeWestern Tennessee is a region of Tennessee. There are many roads that lead in and out of the region. MurfreesboroMurfreesboro is a city in Tennessee. From the Airport - Follow the signs to Interstate 24 East then follow the directions from Nashville below.